Direct trials on the Gheranda Samhita’s exact sequence remain few and far between, but its individual building blocks have sailed through the scientific gauntlet with flying colors.

• Shatkarmas (cleansing techniques): Research on nasal irrigation (jālā netī) shows clear relief for chronic sinusitis—Cochrane’s 2022 review highlighted significant symptom reduction and fewer antibiotic prescriptions. Studies on bhastrika and kapalabhati hint at improved lung function and oxidative stress markers, too.

• Asanas (postures): A 2023 meta-analysis in the International Journal of Environmental Research and Public Health reported that regular Hatha-style postures enhance flexibility, reduce lower-back pain and boost mood. Veterans suffering chronic pain, for instance, logged measurable gains in mobility after six weeks of yoga-based stretching.

• Mudras and Bandhas (gestures and locks): Although large-scale trials are still warming up, pilot studies suggest mula bandha can strengthen pelvic-floor muscles—handy for anyone chasing better core stability. Certain mudras appear to modulate autonomic activity, according to small EEG and heart-rate-variability investigations.

• Pranayama (breath control): This one’s made headlines recently. A 2024 randomized trial published in Frontiers in Psychiatry found alternate-nostril breathing (nadi shodhana) lowered cortisol levels and anxiety scores in college students during exam season. Harvard Medical School also featured breath-work as a “silver lining” strategy for stress resilience in its 2023 Wellness Update.

• Pratyahara, Dharana, Dhyana (withdrawal, concentration, meditation): Mindfulness and meditation are practically household words now. A 2021 systematic review in JAMA Psychiatry linked regular meditation practice with reduced depression risk and sharper working memory. Neuroimaging studies from 2022 show increased gray-matter density in areas governing attention and emotional regulation.

Bottom line: Even if direct “Gheranda Samhita clinical trials” haven’t flooded the literature, its sevenfold approach rests on a solid bedrock of peer-reviewed science. Each limb carries a growing body of evidence—from better sinus health and back pain relief to stress reduction and cognitive gains—making this centuries-old blueprint anything but a relic.